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Bhasma preparations constitute an important class of herbo-mineral formulations in Ayurveda and are extensively used
in Rasashastra therapeutics. Despite their clinical significance, concerns regarding safety, reproducibility, and quality
control have necessitated scientific standardization. Classical Ayurvedic texts describe elaborate procedures including
shodhana, marana, jarana, and amritikarana for detoxification and incineration of metals and minerals. However,
variations in raw materials, processing parameters, heating patterns, and equipment introduce variability in the final
product. Modern regulatory requirements demand validated protocols incorporating physicochemical, spectroscopic, and
toxicological evaluation. This review critically examines the need for standardization in bhasma preparation, classical
guidelines, modern analytical advancements, regulatory perspectives, and prevailing challenges. The integration of
traditional wisdom with contemporary scientific tools is essential to ensure safety, efficacy, and global acceptability of
Ayurvedic metallic formulations (1–4).

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