Pharmacological and Clinical Evaluation of Panchakoladi Lepa: A Review of Transdermal Therapies in the Classical Texts
Abstract
The management of localized inflammation (Shotha) and pain (Shoola) constitutes a significant portion of general medical
practice. While contemporary medicine largely relies on NSAIDs and topical analgesics, the Ayurvedic pharmacopeia
offers a range of transdermal applications known as Lepa. This review critically examines the formulation Panchakoladi
Lepa, a compound cited in the Charaka Samhita comprising five specific pungent herbs. The paper analyzes the rationale
behind this formulation, its putative mechanism of action regarding Kapha-Vata stagnation, and the clinical precautions
required due to its vesicant properties. We posit that Panchakola acts not merely as a counter-irritant, but as a localized
metabolic stimulant (Agni enhancer) capable of penetrating deep tissue barriers.